RIBOZYMES IN GENE THERAPY OF HIV - 1 Janet
نویسندگان
چکیده
1. Abstract 2. Introduction 2.1 The infectious cycle of HIV-1 2.2 Gene therapy approaches to HIV-1 2.3 Designing and testing ribozymes 2.3.1 Choice of the RNA target site 2.3.2 Testing ribozymes by in vitro cleavage 2.3.3 Testing ribozymes in cell culture 2.4 Ribozyme-mediated inhibition of a murine retrovirus 3 Anti-HIV-1 ribozymes 3.1 The potential application of ribozymes to the treatment of AIDS 3.2 Design and testing of anti-HIV-1 ribozymes 3.2.1 Anti-HIV-1 ribozymes in cell culture 3.2.2 Specificity of anti-HIV ribozymes 3.3 Towards an anti-HIV ribozyme gene therapeutic 3.4 Current Phase I clinical trials of an anti-HIV ribozyme 4. Conclusion 5. Acknowledgments 6. References
منابع مشابه
[Frontiers in Bioscience 5, d527-555, May 1, 2000] 527 CURRENT DEVELOMENTS AND FUTURE PROSPECTS FOR HIV GENE THERAPY USING INTERFERING RNA-BASED STRATEGIES
post-integration steps, inhibit/inactivate progeny virus RNA packaging and/or reverse transcription, and use HIV for anti-HIV gene transfer during the subsequent round of infection 3.5.1. Ribozymes 4. Current anti-HIV gene therapy clinical trials using interfering RNA-based strategies 4.1. Antisense RNAs 4.2. Sense RNAs 4.3. Ribozymes 5. Conclusions and future prospects 6. Acknowledgements 7. R...
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تاریخ انتشار 2003